Polymer-Based Bioengineering Solution for the Prophylactic Antiviral Prophylaxis
Broad Spectrum Antiviral Prophylactic Gel: The immunocamouflage technology has also been successfully applied in the development of a broad spectrum anti-viral prophylactic gel. Our studies have documented the effectiveness of the anti-viral gel (e.g., suitable for intranasal administration) against a broad range of RNA and DNA, enveloped and non-enveloped, viruses. The prophylactic nasal gel is easy to apply and gives significant protection against viral invasion for at least 48 hours post application.
Viricade: A broad spectrum antiviral prophylactic gel that physically prevents viral infection at the cell surfaces (e.g., nasal sinus). This product can be applied either prophylactically or following the first onset of symptoms.
Virimmune: Enhanced immune recognition of weakly immunogenic viruses for the development of improved vaccines.
Viricade Exhibits Broad Spectrum Efficacy Against Enveloped and Non-Enveloped RNA and DNA Viruses
Relevant Laboratory Publications
McCoy, L.L and Scott, M.D. Broad spectrum antiviral prophylaxis: Inhibition of viral infection by polymer grafting with methoxypoly(ethylene glycol). In: Antiviral Drug Discovery for Emerging Diseases and Bioterrorism (Editor: Torrence, P.F.) Wiley & Sons, Hoboken, NJ. pp. 379-395.(2005). DOI: https://doi.org/10.1002/0471716715.ch16
Scott, M.D. Inactivation of Prion Proteins Via Covalent Grafting with Methoxypoly(Ethylene Glycol). Medical Hypotheses, 66:387-393(2006). DOI: https://doi.org/10.1016/j.mehy.2005.08.049
Le, Y. and Scott, M.D. Immunocamouflage: The Biophysical Basis of Immunoprotection by Grafted Methoxypoly(Ethylene Glycol) [mPEG]. Acta Biomaterialia, 6:2631-2641 (2010). DOI: https://doi.org/10.1016/j.actbio.2010.01.031
Sutton, T.C. and Scott, M.D. The Effect of Methoxypoly(Ethylene Glycol) Chain Length on the Inhibition Of Respiratory Syncytial Virus (RSV) Infection And Proliferation. Biomaterials, 31:4223-2230 (2010). DOI: https://doi.org/10.1016/j.biomaterials.2010.01.095
Kyluik, D.L., Sutton, T.C., Le, Y. and Scott, M.D. Chapter 7: Polymer-Mediated Broad Spectrum Antiviral Prophylaxis: Utility in High Risk Environments. In: Progress in Molecular and Environmental Bioengineering- From Analysis and Modeling to Technology Applications (Editor: Carpi, A.) Intech, ISBN 978-953-307-268-5. pp. 167-190 (2011). DOI: https://doi.org/10.5772/20920
Le, Y. Li, L., Wang, D. and Scott, M.D. Immunocamouflage of Latex Surfaces by Grafted Methoxypoly(Ethylene Glycol) [mPEG]: Proteomic Analysis of Plasma Protein Adsorption. Science China - Life Sciences, 55:191-201 (2012). [NOTE: Cover Art and featured article] DOI: https://doi.org/10.1007/s11427-012-4290-2