Scott Laboratory - Immios Biologics

Scott Laboratory Website

Canadian Blood Service • University of British Columbia • Centre for Blood Research • Vancouver, BC  Canada


Polymer-Based Bioengineering Solutions for Immune Modulation and the Prophylactic Inhibition of Viral Infections




Scott, M.D., Murad, K.L., Koumpouras, F., Talbot, M., and Eaton, J.W.  Chemical camouflage of antigenic determinants:  “Stealth” erythrocytes.  Proc. Nat. Acad. Sci. USA, 94:7566-7571(1997).

Scott, M.D. and Murad, K.L.  Cellular camouflage:  Fooling the immune system with polymers.  Current Pharmaceutical Design, 4:423-438(1998).

Murad, K.L., Mahany, K.L.  Kuypers, F.A., Brugnara, C., Eaton, J.W, and Scott, M.D.  Structural and functional consequences of antigenic modulation of red cells with methoxypoly(ethylene glycol).  Blood, 93:2121-2127(1999).

Murad, K.L., Gosselin, E.J., Eaton, J.W. Scott, M.D.  Stealth Cells:  Prevention of MHC Class II mediated T cell activation by cell surface modification.  Blood, 94:2135-2141(1999).

Scott, M.D. Bradley, A.J., and Murad, K.L.  Camouflaged Blood Cells:  Low technology bioengineering for transfusion medicine? Transfusion Medicine Reviews, 14:53-63.(2000)

Chen, A.M. and Scott, M.D.  Current and Future Applications of Immunologic Attenuation Via PEGylation of Cells and Tissues.  BioDrugs, 15:833-847(2001).

Bradley, A.J. Test, T.T., Murad, K.L., Mitsuyoshi, J. and  Scott, M.D.  Interactions of IgM ABO Antibodies and complement with methoxy-PEG-modified human RBCs.  Transfusion, 41:1225-1233(2001).

Bradley, A.J., Murad, K.L., Regan, K.L., and Scott, M.D.  Biophysical consequences of linker chemistry and polymer size on stealth erythrocytes:  Size does matter.  Biochimica et Biophysica Acta,  1561:147-58(2002).

Chen, A.M. and Scott, M.D.  Immunocamouflage:  Prevention of transfusion-induced graft-versus-host disease via polymer grafting of donor cells.  Journal of Biomedical Materials Research,  67A:626-636(2003).

Scott, M.D. Bradley, A.J., and Murad, K.L.  Stealth Erythrocytes:  Effects of polymer grafting on biophysical, biological and immunological parameters.  Blood Transfusion, 1(3):245-266(2003).

Scott, M.D., and Chen, A.M.  Beyond the red cell: Pegylation of other blood cells and tissues (Traitement par PEG des celllules sanguines et autres tissus).  Transfusion Clinique et Biologique, 11:40-46(2004).

Bradley, A.J. and Scott, M.D.  Separation and purification of methoxypoly(ethylene glycol) grafted red blood cells via two-phase partitioning.  J. Chromatogr. B., 807:163-168 (2004).

McCoy, L.L and Scott, M.D.  Broad spectrum antiviral prophylaxis:  Inhibition of viral infection by polymer grafting with methoxypoly(ethylene glycol).  In:  Antiviral Drug Discovery for Emerging Diseases and Bioterrorism (Editor: Torrence, P.F.)  Wiley & Sons, Hoboken, NJ. pp. 379-395.(2005).

Chen, A.M. and Scott, M.D.  Immunocamouflage:  Comparative analysis of polymer and linker chemistries on the efficacy of immunocamoulfage of murine cells.  Artificial Cells, Blood Substitutes, and Biotechnology, 34:305-322(2006).

Bradley, A.J. and Scott, M.D.  Immune complex binding by immunocamouflaged [poly(ethylene glycol)] erythrocytes.  Am. J. Hematology, 82:970-975(2007).

Le, Y. and Scott, M.D. Immunocamouflage: The Biophysical Basis of Immunoprotection by Grafted Methoxypoly(Ethylene Glycol) [mPEG].  Acta Biomaterialia, 6:2631-2641 (2010).

Sutton, T.C. and Scott, M.D. The Effect of Methoxypoly(Ethylene Glycol) Chain Length on the Inhibition Of Respiratory Syncytial Virus (RSV) Infection And Proliferation.  Biomaterials, 31:4223-2230 (2010).

Kyluik, D.L., Sutton, T.C., Le, Y. and Scott, M.D.  Chapter 7:  Polymer-Mediated Broad Spectrum Antiviral Prophylaxis: Utility in High Risk Environments.  In: Progress in Molecular and Environmental Bioengineering- From Analysis and Modeling to Technology Applications (Editor: Carpi, A.)  Intech, ISBN 978-953-307-268-5. pp. 167-190 (2011). Link:  Intech Web Page

Wang, D., Kyluik, D.L, Murad, K.L., Toyofuku, W.M., and Scott, M.D.  Polymer-Mediated Immunocamouflage of Red Blood Cells: Effects of Polymer Size on Antigenic and Immunogenic Recognition of Allogeneic Donor Blood Cells. Science China – Life Sciences, 54:589-598 (2011).  [NOTE:  Cover Art and featured article]

Wang, D., Toyofuku, W.M., Chen, A.M. and Scott, M.D. Induction of Immunotolerance via mPEG Grafting to Allogeneic Leukocytes.  Biomaterials 32:9494-9503 (2011).

Wang, D., Toyofuku, W.M., Scott, M.D. The Potential Utility of Methoxypoly(Ethylene Glycol)-Mediated Prevention of Rhesus Blood Group Antigen RhD Recognition in Transfusion Medicine.  Biomaterials, 33:3002-3012. (2012)

Wang, D., Toyofuku, W.M. Kyluik, D.L. and Scott, M.D. Chapter 7:  Use of Flow Cytometry In The In Vitro and In Vivo Analysis of Tolerance/Anergy Induction By Immunocamouflage.  In: Flow Cytometry-Recent Perspectives, (Editor: Schmid, I.) InTech, ISBN 979-953-307-355-1. (2012).  Pages 133-150.  Link:  Intech Web Page

Le, Y. Li, L., Wang, D. and Scott, M.D. Immunocamouflage of Latex Surfaces by Grafted Methoxypoly(Ethylene Glycol) [mPEG]:  Proteomic Analysis of Plasma Protein Adsorption. Science China - Life Sciences, 55:191-201 (2012).  [NOTE:  Cover Art and featured article]

Kyluik-Price D.L., Li, L. and Scott, M.D.  Comparative Efficacy of Blood Cell Immunocamouflage by Membrane Grafting of Methoxypoly(Ethylene Glycol) and Polyethyloxazoline.  Biomaterials 35(1):412-422 (2014).

Li, L., Noumsi, G.T., Kwok, Y.Y.E., Moulds, J.M. and Scott, M.D.  Inhibition of Phagocytic Recognition of Anti-D Opsonized Rh D+ RBC By Polymer-Mediated Immunocamouflage.  American Journal of Hematology, 90(12):1165-1170 (2015).

Wang, D., Shanina , I., Toyofuku, W.M., Horwitz, M.S. and Scott, M.D.  Inhibition of Autoimmune Diabetes in NOD Mice by miRNA Therapy. PLoS ONE 10(12): e0145179. doi:10.1371/journal. pone.0145179 (2015).   Link:  Plosone Paper

Kyluik-Price D.L., Li, L. and Scott, M.D.  Effects of Methoxypoly (Ethylene Glycol) Mediated Immunocamouflage on Leukocyte Surface Marker Detection, Cell Conjugation, Activation and Alloproliferation.  Biomaterials 74(1):167-177 (2016).

Le, Y., Toyofuku, W.M. and Scott, M.D.  Immunogenicity of Murine mPEG-Red Blood Cells and the Risk of Anti-PEG Antibodies in Human Blood Donors.  Experimental Hematology 47(3):36-47 (2017).

Scott, M.D., Toyofuku, W.M., Yang, X., Raj, M. and Kang, N. Chapter X: Immunocamouflaged Red Blood Cells:  Polymer-Based Bioengineering of Allogeneic Erythrocytes for Use in Alloimmunized Patients.  In: Transfusion Medicine (Editor: Koopman-van Gemert, A.), INTECH Book, in press.  ISBN 978-953-51-5473-0 (in press, 2017)

Kang, N., Toyofuku, W.M., Yang, X. and Scott, M.D. Inhibition of Allogeneic Cytotoxic T Cell (CD8+) Proliferation Via Polymer-Induced Treg (CD4+) Cells.  Acta Biomaterialia, in press (2017).

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